Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.60 |
| ▸ | EGFR | P00533 | 8/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.60 |
| ▸ | FECH | P22830 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.55 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476691 | 0.91 | EGFR (0.51) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL4619310 | 0.90 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6483391 | 0.89 | ERBB2 (0.49) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6177639 | 0.88 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL215055 | 0.88 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6173604 | 0.88 | ERBB2 (0.57) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL4616817 | 0.88 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6174169 | 0.86 | ERBB2 (0.55) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL24832693 | 0.85 | ERBB2 (0.68) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6174286 | 0.85 | ERBB2 (0.54) | ERBB2EGFRERBB3ERBB4FECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194596-A1 | Therapeutic Combination Including a Selective Erbb2 Inhibitor | FRIZER INC. | 2008-08-14 | — | — | US | disclosed |
| US-20050101618-A1 | Selective erbB2 inhibitor/anti-erbB antibody combinations in the treatment of cancer | PFIZER INC | 2005-05-12 | — | — | US | disclosed |
| US-6890924-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2005-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101618-A1 | Selective erbB2 inhibitor/anti-erbB antibody combinations in the treatment of cancer | ERBB2, ERBB3, EGFR | ERBB2 1/4885EGFR 3/4885ERBB3 2/4885 |
| US-20080194596-A1 | Therapeutic Combination Including a Selective Erbb2 Inhibitor | ERBB2, ERBB3, EGFR | ERBB2 1/4885EGFR 3/4885ERBB3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.