Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174638 | 0.89 | IGF1R (0.43) | IGF1RNAMPTALDH1A1TP53AR | |
| SCHEMBL6175293 | 0.84 | IGF1R (0.45) | IGF1RNAMPTALDH1A1KDM4ELMNA | |
| SCHEMBL6171403 | 0.83 | IGF1R (0.43) | IGF1RNAMPTALDH1A1LMNATP53 | |
| SCHEMBL6175170 | 0.82 | IGF1R (0.44) | IGF1RNAMPTALDH1A1LMNATP53 | |
| SCHEMBL6175255 | 0.82 | IGF1R (0.44) | IGF1RNAMPTALDH1A1LMNATP53 | |
| SCHEMBL6173238 | 0.82 | IGF1R (0.41) | IGF1RNAMPTALDH1A1KDM4ELMNA | |
| SCHEMBL2934865 | 0.82 | IGF1R (0.65) | IGF1RAR | |
| SCHEMBL6173181 | 0.81 | IGF1R (0.43) | IGF1RNAMPTPTPRZ1LMNATP53 | |
| SCHEMBL6171903 | 0.81 | IGF1R (0.45) | IGF1RNAMPTALDH1A1TP53AR | |
| SCHEMBL6174148 | 0.81 | IGF1R (0.40) | IGF1RNAMPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |