Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174453 | 0.80 | IGF1R (0.40) | IGF1RALDH1A1CA1CA2CA9 | |
| SCHEMBL2938437 | 0.73 | IGF1R (0.47) | IGF1RALDH1A1MAPTGAALMNA | |
| SCHEMBL2940860 | 0.71 | IGF1R (0.54) | IGF1RALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2940492 | 0.69 | IGF1R (0.42) | IGF1RKMT2A | |
| SCHEMBL2936880 | 0.69 | IGF1R (0.53) | IGF1RALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2938325 | 0.69 | IGF1R (0.40) | IGF1RALDH1A1CA1CA2CA9 | |
| SCHEMBL2940999 | 0.68 | IGF1R (0.42) | IGF1RHTTLMNA | |
| SCHEMBL2939128 | 0.68 | IGF1R (0.53) | IGF1RALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2939674 | 0.67 | IGF1R (0.64) | IGF1RALDH1A1HTTLMNA | |
| SCHEMBL2940692 | 0.67 | IGF1R (0.64) | IGF1RALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |