Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174453 | 0.79 | IGF1R (0.40) | IGF1RBRD4CDK9MAPTKDM1A | |
| SCHEMBL2939892 | 0.76 | IGF1R (0.51) | IGF1R | |
| SCHEMBL6173179 | 0.74 | IGF1R (0.49) | IGF1R | |
| SCHEMBL6172653 | 0.74 | IGF1R (0.38) | IGF1R | |
| SCHEMBL6174200 | 0.74 | IGF1R (0.40) | IGF1RPDE2AFPR1FPR2 | |
| SCHEMBL6177675 | 0.73 | SCN10A (0.41) | IGF1RPDE2AHDAC1 | |
| SCHEMBL6171970 | 0.71 | IGF1R (0.41) | IGF1RMAPT | |
| SCHEMBL6171982 | 0.68 | IGF1R (0.41) | IGF1R | |
| SCHEMBL6175120 | 0.67 | IGF1R (0.45) | IGF1R | |
| SCHEMBL3727112 | 0.67 | IGF1R (0.54) | IGF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |