SCHEMBL6174597

SCHEMBL6174597

CC(C)OC(=O)Nc1cc(C(C)C2(C(C)c3ccnc(NC(=O)OC(C)C)c3)NC(=O)N(c3ccc(OC(F)(F)F)cc3)C2=O)ccn1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.38
PDE2A O00408 7/20 0.36
CYP3A4 P08684 2/20 0.35
GAA P10253 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
IGF1R P08069 1/20 0.35
ABL1 P00519 2/20 0.34
AAK1 Q2M2I8 1/20 0.34
BRAF P15056 1/20 0.34
KCNQ3 O43525 1/20 0.34
KCNQ2 O43526 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CBLB Q13191 1/20 0.34
SLC5A1 P13866 1/20 0.34
NTRK1 P04629 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176554 0.91 BRAF (0.42) MAPK1PDE2ACYP3A4GAACYP2C9
SCHEMBL6176257 0.90 MAPT (0.41) MAPK1PDE2ACYP3A4GAACYP2C9
SCHEMBL6176861 0.89 PDE2A (0.39) MAPK1PDE2ACYP3A4GAACYP2C9
SCHEMBL6175414 0.88 MAPK1 (0.36) MAPK1PDE2ACYP3A4GAACYP2C9
SCHEMBL6174504 0.87 IGF1R (0.48) PDE2AIGF1R
SCHEMBL6172274 0.87 CYP3A4 (0.40) MAPK1PDE2ACYP3A4GAACYP2C9
SCHEMBL6171179 0.87 POLB (0.37) MAPK1PDE2ACYP3A4GAACYP2C9
SCHEMBL6173825 0.86 MAPK1 (0.42) MAPK1IGF1RBRAF
SCHEMBL6171136 0.86 CYP3A4 (0.47) PDE2ACYP3A4GAACYP2C9CYP2C19
SCHEMBL6175553 0.86 NPC1 (0.40) MAPK1PDE2ACYP3A4GAACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 WO disclosed