Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | CBLB | Q13191 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175553 | 0.93 | NPC1 (0.40) | CYP3A4GAACYP2C9CYP2C19NTRK1 | |
| SCHEMBL6171136 | 0.93 | CYP3A4 (0.47) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173257 | 0.91 | GRM5 (0.45) | ALDH1A1NTRK1MAPKAPK2ABL1SCN10A | |
| SCHEMBL6176861 | 0.89 | PDE2A (0.39) | CYP3A4GAACYP2C9CYP2C19MAPK1 | |
| SCHEMBL6173825 | 0.89 | MAPK1 (0.42) | MAPK1NPC1RAB9A | |
| SCHEMBL6176554 | 0.89 | BRAF (0.42) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6172794 | 0.88 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL6174597 | 0.87 | MAPK1 (0.38) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173261 | 0.86 | IGF1R (0.41) | MAPKAPK2ABL1 | |
| SCHEMBL6175145 | 0.86 | ALDH1A1 (0.40) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |