Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17558342 | 0.88 | CYP3A4 (0.41) | CYP3A4CYP2C9CYP2C19GAAIGF1R | |
| SCHEMBL6172549 | 0.85 | IGF1R (0.37) | CYP3A4CYP2C9CYP2C19GAAIGF1R | |
| Trifluoroacetic Acid SCHEMBL17558384 | 0.81 | IGF1R (0.51) | IGF1RARALDH1A1NAMPTPTPRZ1 | |
| SCHEMBL6172121 | 0.81 | AR (0.44) | CYP3A4CYP2C9CYP2C19GAAIGF1R | |
| SCHEMBL6178355 | 0.81 | AR (0.44) | CYP3A4CYP2C9CYP2C19GAAIGF1R | |
| Trifluoroacetic Acid SCHEMBL17558354 | 0.79 | AR (0.40) | CYP3A4CYP2C9CYP2C19GAAIGF1R | |
| Trifluoroacetic Acid SCHEMBL17558366 | 0.79 | IGF1R (0.38) | CYP3A4CYP2C9CYP2C19GAAIGF1R | |
| SCHEMBL6172757 | 0.75 | IGF1R (0.57) | IGF1RARALDH1A1NAMPTKMT2A | |
| SCHEMBL2939941 | 0.71 | IGF1R (0.44) | GAAIGF1RALDH1A1PTPRZ1KMT2A | |
| SCHEMBL2939939 | 0.71 | IGF1R (0.44) | GAAIGF1RALDH1A1PTPRZ1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |