Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172757 | 0.92 | IGF1R (0.57) | IGF1RPTGDR2ARNAMPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL17558458 | 0.88 | IGF1R (0.52) | IGF1RPTGDR2ARNAMPTSYK | |
| Trifluoroacetic Acid SCHEMBL17558363 | 0.86 | IGF1R (0.50) | IGF1RPTGDR2ARNAMPT | |
| SCHEMBL6173223 | 0.84 | IGF1R (0.55) | IGF1RARNAMPT | |
| Trifluoroacetic Acid SCHEMBL17558350 | 0.83 | IGF1R (0.60) | IGF1RPTGDR2ARNAMPTSYK | |
| Trifluoroacetic Acid SCHEMBL17558459 | 0.83 | IGF1R (0.60) | IGF1RPTGDR2ARNAMPTSYK | |
| SCHEMBL6172123 | 0.83 | IGF1R (0.38) | IGF1RAR | |
| SCHEMBL17558392 | 0.82 | IGF1R (0.51) | IGF1RARNAMPTSYK | |
| SCHEMBL6174602 | 0.81 | CYP3A4 (0.37) | IGF1RARNAMPTALDH1A1PTPRZ1 | |
| Trifluoroacetic Acid SCHEMBL17558366 | 0.79 | IGF1R (0.38) | IGF1RPTGDR2NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |