SCHEMBL6174744

SCHEMBL6174744

CC(c1ccnc(CN)c1)C1NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 19/20 0.41
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6171919 0.91 IGF1R (0.41) IGF1RLMNA
SCHEMBL6175884 0.88 IGF1R (0.41) IGF1RLMNA
SCHEMBL6174049 0.86 IGF1R (0.46) IGF1RLMNA
SCHEMBL6175986 0.84 IGF1R (0.51) IGF1RLMNA
SCHEMBL6173932 0.84 IGF1R (0.40) IGF1RLMNA
SCHEMBL6174605 0.83 IGF1R (0.42) IGF1R
SCHEMBL6172812 0.83 IGF1R (0.41) IGF1RLMNA
SCHEMBL6173796 0.83 IGF1R (0.52) IGF1R
SCHEMBL6173480 0.83 IGF1R (0.41) IGF1RLMNA
SCHEMBL6174695 0.82 LMNA (0.39) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 WO disclosed