Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1654217 | 0.97 | PDE4B (0.43) | PDE4BTBXAS1PARP1MAPTABCG2 | |
| SCHEMBL1654229 | 0.91 | PDE4B (0.52) | PDE4BPARP1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL3036227 | 0.85 | TBXAS1 (0.55) | PDE4BTBXAS1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL3029504 | 0.85 | PDE4B (0.56) | PDE4BTBXAS1PARP1ALDH1A1MEN1 | |
| SCHEMBL1652540 | 0.85 | PDE4B (0.56) | PDE4BTBXAS1ABCG2ALDH1A1L3MBTL1 | |
| SCHEMBL1651617 | 0.83 | PDE4B (0.54) | PDE4BTBXAS1PARP1MAPTALDH1A1 | |
| SCHEMBL3033443 | 0.82 | PDE4B (0.59) | PDE4BPARP1MAPTMEN1KMT2A | |
| SCHEMBL3036159 | 0.82 | PDE4B (0.56) | PDE4BTBXAS1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL1653670 | 0.82 | PDE4B (0.59) | PDE4BKMT2A | |
| SCHEMBL3022322 | 0.82 | PDE4B (0.49) | PDE4BTBXAS1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058729-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL PRODESFARMA SA (ES) | 2004-07-15 | — | — | WO | disclosed |