Sugi Predict

Sugi Predict / Compounds / SCHEMBL6174841

SCHEMBL6174841

SCHEMBL6174841

CC(c1ccncc1Cc1ccccc1)C1(C(C)c2ccncc2Cc2ccccc2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 16/20 0.42
▸ LMNA P02545 1/20 0.33
▸ PTPN1 P18031 1/20 0.32
▸ PTPRZ1 P23471 1/20 0.32
▸ NTRK1 P04629 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6173174 0.89 IGF1R (0.44) IGF1RNTRK1
SCHEMBL6174958 0.87 IGF1R (0.43) IGF1RNTRK1
SCHEMBL6173753 0.87 IGF1R (0.43) IGF1RLMNANTRK1
SCHEMBL6173913 0.87 IGF1R (0.43) IGF1RNTRK1
SCHEMBL6172500 0.85 IGF1R (0.39) IGF1RLMNA
SCHEMBL6173832 0.85 IGF1R (0.40) IGF1RLMNA
SCHEMBL6173549 0.83 IGF1R (0.43) IGF1R
SCHEMBL6174310 0.83 IGF1R (0.43) IGF1R
SCHEMBL6174921 0.83 IGF1R (0.43) IGF1R
SCHEMBL6172761 0.82 IGF1R (0.42) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed