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SCHEMBL6174902

SCHEMBL6174902

CNc1ccc2nccc(C(C)C3NC(=O)N(c4ccc(SC(F)(F)F)cc4)C3=O)c2c1

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ IGF1R P08069 18/20 0.38
▸ LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6174393 0.89 SMN1; SMN2 (0.43) SMN1; SMN2IGF1RLMNA
SCHEMBL6172293 0.86 IGF1R (0.40) SMN1; SMN2IGF1RLMNA
SCHEMBL6174287 0.83 IGF1R (0.38) SMN1; SMN2IGF1RLMNA
SCHEMBL6173610 0.83 IGF1R (0.37) SMN1; SMN2IGF1RLMNA
SCHEMBL6175392 0.81 IGF1R (0.36) SMN1; SMN2IGF1RLMNA
SCHEMBL6175589 0.81 IGF1R (0.38) SMN1; SMN2IGF1RLMNA
SCHEMBL6174916 0.80 IGF1R (0.35) SMN1; SMN2IGF1R
SCHEMBL6172678 0.79 IGF1R (0.41) SMN1; SMN2IGF1R
SCHEMBL6172547 0.79 IGF1R (0.41) IGF1RLMNA
SCHEMBL6176324 0.78 IGF1R (0.35) SMN1; SMN2IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed