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Sugi Predict / Compounds / SCHEMBL6175589

SCHEMBL6175589

SCHEMBL6175589

CC(c1ccnc2cc(N(C)C)ccc12)C1NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 17/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ PDE2A O00408 1/20 0.31
▸ LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6174287 0.89 IGF1R (0.38) IGF1RSMN1; SMN2LMNA
SCHEMBL6173610 0.89 IGF1R (0.37) IGF1RSMN1; SMN2LMNA
SCHEMBL6174916 0.85 IGF1R (0.35) IGF1RSMN1; SMN2PDE2A
SCHEMBL6174393 0.83 SMN1; SMN2 (0.43) IGF1RSMN1; SMN2LMNA
SCHEMBL6174880 0.81 IGF1R (0.36) IGF1RLMNA
SCHEMBL6172293 0.81 IGF1R (0.40) IGF1RSMN1; SMN2LMNA
SCHEMBL6174902 0.81 SMN1; SMN2 (0.39) IGF1RSMN1; SMN2LMNA
SCHEMBL6172540 0.81 IGF1R (0.36) IGF1RSMN1; SMN2PDE2ALMNA
SCHEMBL6174905 0.79 IGF1R (0.41) IGF1RSMN1; SMN2
SCHEMBL6173280 0.79 IGF1R (0.42) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed