Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.62 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174935 | 1.00 | SLC7A5 (0.62) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA | |
| Valine SCHEMBL6267142 | 0.81 | SLC7A5 (0.83) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA | |
| Valine SCHEMBL1933771 | 0.79 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA | |
| SCHEMBL6946495 | 0.78 | — | — | |
| Valine SCHEMBL482773 | 0.78 | SLC7A5 (0.88) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA | |
| Valine SCHEMBL27571970 | 0.78 | SLC7A5 (0.88) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA | |
| Valine SCHEMBL15602719 | 0.78 | SLC7A5 (0.88) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA | |
| SCHEMBL2485612 | 0.78 | — | — | |
| Valine SCHEMBL20840066 | 0.78 | SLC7A5 (0.88) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| SCHEMBL5283278 | 0.78 | SLC7A5 (0.46) | SLC7A5SLC1A3SLC1A2SLC1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939565-B2 | Protease inhibitors of the coagulation cascade isolated from Dysidea sponges | PHARMACIA CORPORATION (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1465866-A4 | PROTEASE INHIBITORS OF THE COAGULATION CASCADE ISOLATED FROM DYSIDEA SPONGES | PHARMACIA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1465866-A2 | PROTEASE INHIBITORS OF THE COAGULATION CASCADE ISOLATED FROM DYSIDEA SPONGES | Pharmacia Corporation (US) | 2004-10-13 | — | — | EP | disclosed |
| US-20040147456-A1 | Protease inhibitors of the coagulation cascade isolated from Dysidea sponges | PHARMACIA CORPORATION | 2004-07-29 | — | — | US | disclosed |
| US-6716869-B2 | N-(2-(1-AMIDINOPYRROL-3-YL)ETHYL)-5,6-DIHYDROXY-1-(2-(2-METHOX Y-3-SULFATOPROPIONYLAMINO)-3-CHLORO-4-METHYLVALEROYL)INDOLE-2-CARBOXAMIDE | PHARMACIA CORPORATION | 2004-04-06 | — | — | US | disclosed |
| US-20030158248-A1 | Protease inhibitors of the coagulation cascade isolated from dysidea sponges | PHARMACIA CORPORATION | 2003-08-21 | — | — | US | disclosed |
| WO-2003051831-A2 | PROTEASE INHIBITORS OF THE COAGULATION CASCADE ISOLATED FROM DYSIDEA SPONGES | PHARMACIA CORPORATION (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147456-A1 | Protease inhibitors of the coagulation cascade isolated from Dysidea sponges | TFPI, TFPI2, HABP2 | SLC7A5 4648/4885SLC1A3 4846/4885SLC1A2 4870/4885 |
| US-20030158248-A1 | Protease inhibitors of the coagulation cascade isolated from dysidea sponges | TFPI, TFPI2, HABP2 | SLC7A5 4648/4885SLC1A3 4846/4885SLC1A2 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.