Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173900 | 0.92 | IGF1R (0.42) | IGF1RALDH1A1AR | |
| SCHEMBL6174729 | 0.88 | IGF1R (0.37) | IGF1RALDH1A1 | |
| SCHEMBL6174307 | 0.86 | CYP2C9 (0.38) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6172850 | 0.85 | IGF1R (0.35) | IGF1RCYP2C9CYP2C19 | |
| SCHEMBL6172761 | 0.84 | IGF1R (0.42) | IGF1RALDH1A1KMT2A | |
| SCHEMBL6174921 | 0.83 | IGF1R (0.43) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6174310 | 0.83 | IGF1R (0.43) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6173549 | 0.83 | IGF1R (0.43) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6172115 | 0.82 | IGF1R (0.37) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6174958 | 0.82 | IGF1R (0.43) | IGF1RALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |