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Sugi Predict / Compounds / SCHEMBL6174729

SCHEMBL6174729

SCHEMBL6174729

CC(c1ccncc1NS(=O)(=O)Nc1ccccc1)C1(C(C)c2ccncc2NS(=O)(=O)Nc2ccccc2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 11/20 0.37
▸ PTGS1 P23219 4/20 0.33
▸ PTGS2 P35354 4/20 0.33
▸ LMNA P02545 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ NTRK1 P04629 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6172761 0.89 IGF1R (0.42) IGF1RPTGS1PTGS2LMNAALDH1A1
SCHEMBL6173900 0.88 IGF1R (0.42) IGF1RPTGS1PTGS2ALDH1A1
SCHEMBL6174952 0.88 IGF1R (0.38) IGF1RALDH1A1
SCHEMBL6172208 0.83 KCNK2 (0.41) IGF1RLMNAALDH1A1
SCHEMBL6172850 0.82 IGF1R (0.35) IGF1R
SCHEMBL6173832 0.81 IGF1R (0.40) IGF1RLMNAALDH1A1
SCHEMBL6175455 0.81 LMNA (0.35) IGF1RPTGS1PTGS2LMNANTRK1
SCHEMBL6175453 0.81 IGF1R (0.40) IGF1RPTGS1PTGS2NTRK1
SCHEMBL6174310 0.80 IGF1R (0.43) IGF1RALDH1A1
SCHEMBL6174921 0.80 IGF1R (0.43) IGF1RALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed