Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173148 | 0.91 | IGF1R (0.40) | IGF1RMAPK1TSHRKMT2AEPHX2 | |
| SCHEMBL6175976 | 0.89 | IGF1R (0.41) | IGF1RTSHRKMT2AITGAL | |
| SCHEMBL6176131 | 0.89 | SMN1; SMN2 (0.39) | IGF1RTSHRKMT2AEPHX2PTGS2 | |
| SCHEMBL6175060 | 0.88 | IGF1R (0.41) | IGF1RMAPK1TSHRKMT2AITGAL | |
| SCHEMBL6169398 | 0.88 | IGF1R (0.49) | IGF1RTSHRKMT2ANTRK1EPHX2 | |
| SCHEMBL6173180 | 0.85 | IGF1R (0.40) | IGF1RTSHRKMT2AITGAL | |
| SCHEMBL6175032 | 0.85 | MAPK1 (0.43) | IGF1RMAPK1NAMPTKMT2AEPHX2 | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | IGF1RTSHRKMT2AITGALGPR39 | |
| SCHEMBL6172683 | 0.83 | MAPK1 (0.38) | IGF1RMAPK1NAMPTTSHRKMT2A | |
| SCHEMBL6222480 | 0.82 | MAPT (0.46) | IGF1RITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |