Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175034 | 0.91 | IGF1R (0.40) | IGF1REPHX2PTGS2TSHRKMT2A | |
| SCHEMBL6175976 | 0.90 | IGF1R (0.41) | IGF1RTSHRKMT2AITGALAR | |
| SCHEMBL6176131 | 0.89 | SMN1; SMN2 (0.39) | IGF1REPHX2PTGS2TSHRKMT2A | |
| SCHEMBL6169398 | 0.88 | IGF1R (0.49) | IGF1REPHX2TSHRKMT2AABL1 | |
| SCHEMBL6173180 | 0.86 | IGF1R (0.40) | IGF1RTSHRKMT2AITGALAR | |
| SCHEMBL6173728 | 0.85 | MEN1 (0.47) | IGF1REPHX2PTGS2KMT2AIDH1 | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | IGF1RTSHRKMT2AITGALAR | |
| SCHEMBL6222480 | 0.83 | MAPT (0.46) | IGF1RITGALLIPEALDH1A1 | |
| SCHEMBL2938136 | 0.82 | IGF1R (0.61) | IGF1R | |
| SCHEMBL6171765 | 0.82 | IGF1R (0.41) | IGF1REPHX2PTGS2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |