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Sugi Predict / Compounds / SCHEMBL6175074

SCHEMBL6175074

SCHEMBL6175074

CC(c1ccnc(-c2ccccc2Cl)c1)C1NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 16/20 0.37
▸ LMNA P02545 1/20 0.35
▸ AVPR2 P30518 1/20 0.32
▸ AVPR1A P37288 1/20 0.32
▸ MAPKAPK2 P49137 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6174695 0.88 LMNA (0.39) IGF1RLMNAMAPKAPK2
SCHEMBL6174656 0.86 LMNA (0.41) LMNAAVPR2AVPR1A
SCHEMBL6175552 0.86 IGF1R (0.38) IGF1RLMNA
SCHEMBL6170257 0.85 IGF1R (0.39) IGF1RLMNAAVPR2AVPR1AMAPKAPK2
SCHEMBL6173240 0.83 IGF1R (0.37) IGF1RLMNA
SCHEMBL6174049 0.82 IGF1R (0.46) IGF1RLMNA
SCHEMBL6175934 0.81 IGF1R (0.41) IGF1R
SCHEMBL6174200 0.81 IGF1R (0.40) IGF1RLMNA
SCHEMBL6175884 0.81 IGF1R (0.41) IGF1RLMNA
SCHEMBL6173932 0.80 IGF1R (0.40) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed