Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.32 |
| ▸ | CCR7 | P32248 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173577 | 0.88 | IGF1R (0.39) | IGF1RHRH4LMNATRPV3MAPK1 | |
| SCHEMBL6174834 | 0.86 | GRM1 (0.39) | IGF1RLMNAMAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL6175008 | 0.86 | IGF1R (0.39) | IGF1RHRH4LMNATRPV3MAPK1 | |
| SCHEMBL6174486 | 0.84 | IGF1R (0.38) | IGF1RHRH4LMNATRPV3NR1H3 | |
| SCHEMBL6175530 | 0.84 | IGF1R (0.37) | IGF1RHRH4LMNATRPV3SMN1; SMN2 | |
| SCHEMBL6172969 | 0.83 | DHODH (0.38) | IGF1RSMN1; SMN2 | |
| SCHEMBL6173894 | 0.83 | IGF1R (0.37) | IGF1RHRH4LMNATRPV3KIF11 | |
| SCHEMBL6172236 | 0.83 | IGF1R (0.39) | IGF1RHRH4LMNATRPV3MAPK1 | |
| SCHEMBL6177752 | 0.82 | IGF1R (0.37) | IGF1RLMNATRPV3 | |
| SCHEMBL6173484 | 0.81 | HRH4 (0.38) | IGF1RHRH4LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |