Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | CBLB | Q13191 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175142 | 0.86 | IGF1R (0.38) | IGF1REPHX2SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6175179 | 0.86 | ABL1 (0.44) | GRM1TRPV1EPHX2NPC1RAB9A | |
| SCHEMBL6172969 | 0.84 | DHODH (0.38) | IGF1RSMN1; SMN2 | |
| SCHEMBL6174034 | 0.83 | CBLB (0.36) | IGF1RCBLBHTR2ATSPOGPR183 | |
| SCHEMBL6174217 | 0.83 | IGF1R (0.38) | IGF1RCBLBHTR2ATSPOGPR183 | |
| SCHEMBL6173893 | 0.82 | LMNA (0.39) | IGF1RCBLBHTR2ATSPOGPR183 | |
| SCHEMBL6172184 | 0.82 | NPC1 (0.39) | IGF1RCBLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6176514 | 0.81 | NAMPT (0.41) | IGF1RMAPK1 | |
| SCHEMBL6175133 | 0.81 | GRM5 (0.43) | CBLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL6177896 | 0.80 | LMNA (0.48) | IGF1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |