Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.44 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172608 | 0.83 | IGF1R (0.46) | IGF1REGLN2EGLN1EGLN3 | |
| SCHEMBL2940203 | 0.82 | IGF1R (0.44) | IGF1RGCGR | |
| SCHEMBL2939387 | 0.81 | IGF1R (0.56) | IGF1RNTRK1 | |
| SCHEMBL6174193 | 0.77 | IGF1R (0.48) | IGF1R | |
| SCHEMBL2939460 | 0.75 | IGF1R (0.77) | IGF1RGCGR | |
| SCHEMBL2940116 | 0.74 | IGF1R (0.69) | IGF1R | |
| SCHEMBL2939506 | 0.73 | IGF1R (0.50) | IGF1RGCGR | |
| SCHEMBL2931702 | 0.73 | IGF1R (0.60) | IGF1RGCGR | |
| SCHEMBL2937083 | 0.73 | IGF1R (0.52) | IGF1R | |
| SCHEMBL2936903 | 0.72 | IGF1R (0.72) | IGF1RCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |