Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174016 | 0.92 | IGF1R (0.41) | IGF1RKDRFLT1PPARGMAPT | |
| SCHEMBL6172735 | 0.90 | IGF1R (0.42) | IGF1RKDRFLT1MAPTSLC5A1 | |
| SCHEMBL6174444 | 0.89 | IGF1R (0.52) | IGF1RMCHR1 | |
| SCHEMBL6174414 | 0.88 | IGF1R (0.38) | IGF1RMAPTCYP2C9AR | |
| SCHEMBL6173624 | 0.84 | IGF1R (0.42) | IGF1RKDRFLT1CYP3A4GAA | |
| SCHEMBL6171765 | 0.84 | IGF1R (0.41) | IGF1RKDRFLT1SLC5A1CYP3A4 | |
| SCHEMBL2941442 | 0.84 | IGF1R (0.58) | IGF1RPPARDPPARAPPARG | |
| SCHEMBL6174276 | 0.83 | MAPK1 (0.34) | IGF1RMCHR1KDRMAPTSLC5A1 | |
| SCHEMBL6172079 | 0.81 | IGF1R (0.47) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6175090 | 0.81 | IGF1R (0.54) | IGF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |