Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175032 | 0.89 | MAPK1 (0.43) | IGF1REPHX2PTGS2KMT2AMEN1 | |
| SCHEMBL6173728 | 0.89 | MEN1 (0.47) | IGF1REPHX2PTGS2KMT2AMEN1 | |
| SCHEMBL6172735 | 0.89 | IGF1R (0.42) | IGF1REPHX2SLC5A1ARCYP3A4 | |
| SCHEMBL6173886 | 0.88 | IGF1R (0.40) | IGF1REPHX2PTGS2KMT2ATSHR | |
| SCHEMBL6173624 | 0.88 | IGF1R (0.42) | IGF1RARCYP3A4GAACYP2C9 | |
| SCHEMBL6174016 | 0.87 | IGF1R (0.41) | IGF1RTSHRSLC5A1ARCYP3A4 | |
| SCHEMBL6173853 | 0.87 | IGF1R (0.37) | IGF1REPHX2PTGS2KMT2AKCNH2 | |
| SCHEMBL6177003 | 0.85 | TDP1 (0.42) | IGF1RKMT2AGAAKDR | |
| SCHEMBL6177217 | 0.85 | TLR7 (0.39) | IGF1RCYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | IGF1RKMT2ATSHRARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |