Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171811 | 0.90 | IGF1R (0.47) | IGF1RKMT2AMAPTARTHRB | |
| SCHEMBL6170972 | 0.88 | IGF1R (0.45) | IGF1RKMT2AMAPTARCYP2C9 | |
| SCHEMBL6175506 | 0.88 | IGF1R (0.45) | IGF1RKMT2AMAPTARTP53 | |
| SCHEMBL6176730 | 0.79 | IGF1R (0.46) | IGF1RHDAC6CNR1SMN1; SMN2LMNA | |
| SCHEMBL6176726 | 0.79 | IGF1R (0.50) | IGF1RKMT2AMAPTARCYP2C9 | |
| SCHEMBL6171829 | 0.78 | IGF1R (0.42) | IGF1RKMT2AMAPTARCYP2C9 | |
| SCHEMBL6173870 | 0.78 | IGF1R (0.43) | IGF1RKMT2AMAPTARCYP2C9 | |
| SCHEMBL6174716 | 0.77 | KMT2A (0.36) | IGF1RKMT2AMAPTARCYP2C9 | |
| SCHEMBL6172518 | 0.76 | IGF1R (0.42) | IGF1RKMT2AMAPTCYP2C9THRB | |
| SCHEMBL6174619 | 0.76 | IGF1R (0.43) | IGF1RKMT2AMAPTARCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |