Sugi Predict

Sugi Predict / Compounds / SCHEMBL6176730

SCHEMBL6176730

SCHEMBL6176730

CC(c1c(Cl)cnc2ccccc12)C1NC(=O)N(c2ccc(S(=O)(=O)C(F)(F)F)cc2)C1=O

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.46
▸ LMNA P02545 1/20 0.36
▸ HDAC6 Q9UBN7 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ CNR1 P21554 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6171156 0.91 IGF1R (0.47) IGF1RLMNASMN1; SMN2
SCHEMBL6173669 0.89 IGF1R (0.46) IGF1RLMNA
SCHEMBL6173422 0.88 IGF1R (0.45) IGF1RLMNA
SCHEMBL6175899 0.85 IGF1R (0.42) IGF1RLMNAHDAC6SMN1; SMN2
SCHEMBL6174256 0.85 LMNA (0.36) IGF1RLMNAHDAC6SMN1; SMN2
SCHEMBL6175309 0.79 IGF1R (0.46) IGF1RLMNAHDAC6SMN1; SMN2CNR1
SCHEMBL6173471 0.78 IGF1R (0.42) IGF1RLMNA
SCHEMBL6173570 0.78 IGF1R (0.43) IGF1RLMNA
SCHEMBL6174264 0.78 IGF1R (0.43) IGF1RLMNASMN1; SMN2
SCHEMBL6171408 0.77 IGF1R (0.35) IGF1RLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed