Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175447 | 0.89 | MAPK14 (0.45) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6179169 | 0.83 | MAPK14 (0.63) | MAPK14KDM4EMAPTCSNK1DCSNK1E | |
| SCHEMBL6176832 | 0.83 | MAPK14 (0.63) | MAPK14KDM4EMAPTCSNK1DCSNK1E | |
| SCHEMBL7138225 | 0.83 | MAPK14 (0.55) | MAPK14KDM4EMAPTCSNK1DCSNK1E | |
| SCHEMBL4343331 | 0.83 | MAPK14 (0.71) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6177420 | 0.82 | MAPK14 (0.57) | MAPK14KDM4EMAPTCSNK1DCSNK1E | |
| SCHEMBL6175636 | 0.82 | MAPK14 (0.51) | MAPK14KDM4EMAPTCSNK1DCSNK1E | |
| SCHEMBL6178426 | 0.81 | MAPK14 (0.56) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6180619 | 0.81 | MAPK14 (0.53) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6177363 | 0.81 | MAPK14 (0.52) | MAPK14KDM4EMAPTCSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |