Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175337 | 0.89 | MAPK14 (0.50) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4348734 | 0.84 | MAPK14 (0.63) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6177634 | 0.81 | MAPK14 (0.49) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6176484 | 0.80 | MAPK14 (0.53) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4348737 | 0.79 | MAPK14 (0.49) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4338046 | 0.78 | MAPK14 (0.65) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6176488 | 0.77 | MAPK14 (0.45) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6179804 | 0.77 | MAPK14 (0.63) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6176832 | 0.72 | MAPK14 (0.63) | MAPK14CSNK1DCSNK1E | |
| SCHEMBL6179169 | 0.72 | MAPK14 (0.63) | MAPK14CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |