Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.54 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | NPY4R | P50391 | 2/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175659 | 1.00 | MAPK14 (0.54) | MAPK14GPR142CDC7MAPK13MAPK12 | |
| SCHEMBL6181407 | 0.82 | MAPK14 (0.58) | MAPK14GPR142MAPK13MAPK12MAPK11 | |
| SCHEMBL27545016 | 0.82 | MAPK14 (0.58) | MAPK14GPR142MAPK13MAPK12MAPK11 | |
| SCHEMBL7132730 | 0.79 | MAPK14 (0.58) | MAPK14GPR142 | |
| SCHEMBL27577377 | 0.79 | MAPK14 (0.58) | MAPK14GPR142 | |
| Hydrochloric Acid SCHEMBL6177983 | 0.79 | MAPK14 (0.60) | MAPK14CDC7MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL27545007 | 0.79 | MAPK14 (0.60) | MAPK14CDC7MAPK13MAPK12MAPK11 | |
| SCHEMBL6076504 | 0.78 | MAPK14 (0.67) | MAPK14CDC7MAPK13MAPK12MAPK11 | |
| SCHEMBL6176087 | 0.78 | MAPK14 (0.63) | MAPK14CDC7MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL6177211 | 0.77 | MAPK14 (0.58) | MAPK14CDC7MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |