Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.56 |
| ▸ | CIT | O14578 | 8/20 | 0.43 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27545016 | 1.00 | MAPK14 (0.58) | MAPK14AAK1CITLARS1MAPK13 | |
| Hydrochloric Acid SCHEMBL27545007 | 0.87 | MAPK14 (0.60) | MAPK14AAK1MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL6177983 | 0.87 | MAPK14 (0.60) | MAPK14AAK1MAPK13MAPK12MAPK11 | |
| SCHEMBL6176087 | 0.86 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL6177211 | 0.85 | MAPK14 (0.58) | MAPK14AAK1CITMAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL27577373 | 0.85 | MAPK14 (0.58) | MAPK14AAK1CITMAPK13MAPK12 | |
| SCHEMBL7132730 | 0.83 | MAPK14 (0.58) | MAPK14CITGPR142 | |
| SCHEMBL27577377 | 0.83 | MAPK14 (0.58) | MAPK14CITGPR142 | |
| SCHEMBL6178024 | 0.83 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6175641 | 0.82 | MAPK14 (0.54) | MAPK14AAK1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |