Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30845519 | 0.81 | MEN1 (0.46) | KDM4EMEN1NSD2POLBMAPT | |
| SCHEMBL471441 | 0.81 | ERN1 (0.50) | AKR1C2AKR1C1KDM4EMEN1NSD2 | |
| SCHEMBL6175983 | 0.81 | CSNK2A1 (0.50) | AKR1C2AKR1C1HCAR1KDM4EHMGB1 | |
| SCHEMBL22133771 | 0.81 | MEN1 (0.46) | KDM4EMEN1NSD2POLBMAPT | |
| SCHEMBL29794231 | 0.81 | ERN1 (0.50) | AKR1C2AKR1C1KDM4EMEN1NSD2 | |
| SCHEMBL23302962 | 0.79 | HMGB1 (0.58) | KEAP1AKR1C2AKR1C1HCAR1KDM4E | |
| SCHEMBL138319 | 0.79 | ALDH1A1 (0.55) | AKR1C2AKR1C1KDM4EHMGB1CXCL12 | |
| SCHEMBL11302359 | 0.79 | TTR (0.41) | AKR1C2AKR1C1KDM4EHMGB1CXCL12 | |
| SCHEMBL6175731 | 0.79 | AKR1C3 (0.64) | AKR1C2AKR1C1KDM4EHMGB1CXCL12 | |
| SCHEMBL6175638 | 0.79 | AKR1C2 (0.64) | AKR1C2AKR1C1HCAR1KDM4EHMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111875570-A | Synthetic method of fluorine-containing carboxylic acid flavone-amino acid derivative | 郑州师范学院 | 2020-11-03 | — | — | CN | claimed |
| CN-111875570-A | Synthetic method of fluorine-containing carboxylic acid flavone-amino acid derivative | 郑州师范学院 | 2020-11-03 | — | — | CN | disclosed |
| EP-0834510-B1 | Flavone derivative and medicine comprising the same | KOWA CO (JP) | 2005-02-23 | — | — | EP | disclosed |
| EP-0902007-B1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2003-11-05 | — | — | EP | disclosed |
| US-6136848-A | ANTIALLERGENS; ASTHMA THERAPY | KOWA CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| US-6046212-A | ANTIALLERGIC AGENTS | KOWA CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0902007-A1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO. LTD. (JP) | 1999-03-17 | — | — | EP | disclosed |
| EP-0834510-A2 | Flavone derivative and medicine comprising the same | KOWA CO. LTD. (JP) | 1998-04-08 | — | — | EP | disclosed |
| US-4146631-A | ANTIALLERGENS, RESPIRATORY DISORDERS | MAY & BAKER LIMITED (GB) | 1979-03-27 | — | — | US | disclosed |