Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PAM | P19021 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803605 | 0.85 | MAPT (0.64) | MAPTSMN1; SMN2ALDH1A1MAOBRAB9A | |
| SCHEMBL1803603 | 0.85 | MAPT (0.64) | MAPTSMN1; SMN2ALDH1A1MAOBRAB9A | |
| SCHEMBL1803606 | 0.85 | MAPT (0.64) | MAPTSMN1; SMN2ALDH1A1MAOBRAB9A | |
| SCHEMBL10975917 | 0.81 | TDP1 (0.69) | TSHRTDP1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10975921 | 0.81 | TDP1 (0.69) | TSHRTDP1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11109921 | 0.81 | MAPT (0.71) | TSHRTDP1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15709280 | 0.81 | MAPT (0.71) | TSHRTDP1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11109939 | 0.81 | MAPT (0.71) | TSHRTDP1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14966877 | 0.79 | PAM (0.50) | TSHRTDP1ALDH1A1POLBCYP2C9 | |
| SCHEMBL14966874 | 0.79 | PAM (0.50) | TSHRTDP1ALDH1A1POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339683-A4 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2005-07-27 | — | — | EP | disclosed |
| EP-1339683-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002041835-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2002-05-30 | — | — | WO | disclosed |