Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174312 | 0.89 | POLB (0.40) | POLBL3MBTL1NTRK1ACP1IGF1R | |
| SCHEMBL6175476 | 0.88 | IGF1R (0.43) | POLBL3MBTL1NTRK1ACP1IGF1R | |
| SCHEMBL6173653 | 0.88 | BACE1 (0.38) | POLBL3MBTL1NTRK1ACP1IGF1R | |
| SCHEMBL6172147 | 0.88 | POLB (0.37) | POLBL3MBTL1NTRK1ACP1IGF1R | |
| SCHEMBL6175470 | 0.87 | ACP1 (0.41) | POLBL3MBTL1NTRK1CTNNB1TCF7L2 | |
| SCHEMBL6177111 | 0.86 | IGF1R (0.40) | IGF1RLMNAPDE2A | |
| SCHEMBL6172518 | 0.85 | IGF1R (0.42) | L3MBTL1IGF1RLMNAMAPK1 | |
| SCHEMBL6175541 | 0.84 | MCHR1 (0.41) | POLBL3MBTL1ACP1MGLLCASR | |
| SCHEMBL6175751 | 0.83 | AR (0.41) | POLBL3MBTL1IGF1RGPR139CXCR3 | |
| SCHEMBL6172636 | 0.80 | KDM4E (0.35) | POLBL3MBTL1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |