Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941262 | 0.79 | IGF1R (0.60) | IGF1RHCRTR1HCRTR2 | |
| SCHEMBL2940771 | 0.79 | IGF1R (0.60) | IGF1RHCRTR1HCRTR2 | |
| SCHEMBL2940768 | 0.79 | IGF1R (0.60) | IGF1RHCRTR1HCRTR2 | |
| Trifluoroacetic Acid SCHEMBL3728810 | 0.77 | IGF1R (0.42) | IGF1RHDAC6MEN1MAPTKMT2A | |
| SCHEMBL31573040 | 0.74 | IGF1R (0.57) | IGF1R | |
| Trifluoroacetic Acid SCHEMBL3726606 | 0.74 | IGF1R (0.54) | IGF1RHCRTR1HCRTR2 | |
| Trifluoroacetic Acid SCHEMBL3734827 | 0.74 | IGF1R (0.54) | IGF1RHCRTR1HCRTR2 | |
| SCHEMBL2936591 | 0.73 | IGF1R (0.58) | IGF1RHCRTR1HCRTR2 | |
| SCHEMBL2936597 | 0.73 | IGF1R (0.58) | IGF1RHCRTR1HCRTR2 | |
| SCHEMBL6176351 | 0.71 | IGF1R (0.46) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |