Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174328 | 0.87 | GAA (0.41) | GAACYP3A4CYP2C9CYP2C19NAMPT | |
| SCHEMBL2937249 | 0.81 | IGF1R (0.47) | IGF1RGAANAMPTCNR2ALDH1A1 | |
| SCHEMBL2938437 | 0.75 | IGF1R (0.47) | IGF1RGAANAMPTLMNACNR2 | |
| SCHEMBL2939364 | 0.75 | CNR2 (0.39) | IGF1RGAANAMPTCNR2ALDH1A1 | |
| SCHEMBL6172506 | 0.75 | NAMPT (0.40) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL17558354 | 0.72 | AR (0.40) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6172121 | 0.71 | AR (0.44) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6178355 | 0.71 | AR (0.44) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6176592 | 0.69 | IGF1R (0.38) | IGF1RGAANAMPTLMNAALDH1A1 | |
| SCHEMBL2938557 | 0.69 | IGF1R (0.61) | IGF1RNAMPTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |