Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 6/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174332 | 0.86 | CACNA1H (0.40) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2938437 | 0.71 | IGF1R (0.47) | IGF1RPTGDR2NAMPTGAAALDH1A1 | |
| SCHEMBL6176591 | 0.69 | IGF1R (0.40) | IGF1RNAMPTGAAALDH1A1MAPT | |
| SCHEMBL6176622 | 0.69 | IGF1R (0.40) | IGF1RNAMPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2937249 | 0.68 | IGF1R (0.47) | IGF1RPTGDR2NAMPTGAAALDH1A1 | |
| SCHEMBL2940490 | 0.68 | IGF1R (0.61) | IGF1RNAMPTGAAALDH1A1MAPT | |
| SCHEMBL2939364 | 0.67 | CNR2 (0.39) | IGF1RPTGDR2NAMPTGAAALDH1A1 | |
| SCHEMBL6171910 | 0.66 | NAMPT (0.47) | NAMPT | |
| SCHEMBL6172506 | 0.66 | NAMPT (0.40) | IGF1RNAMPTGAAALDH1A1RORC | |
| SCHEMBL6173243 | 0.66 | METAP2 (0.37) | IGF1RNAMPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |