Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9293075 | 0.89 | AR (0.46) | MBOAT4CYP19A1ARKCNH2 | |
| SCHEMBL9113552 | 0.84 | AR (0.64) | ARKCNH2 | |
| SCHEMBL14300609 | 0.84 | AR (0.64) | ARKCNH2 | |
| SCHEMBL9221841 | 0.84 | AR (0.64) | ARKCNH2 | |
| SCHEMBL7854363 | 0.80 | AR (0.44) | MBOAT4CYP19A1ARKCNH2 | |
| SCHEMBL15121576 | 0.74 | AR (0.42) | MBOAT4CYP19A1ARKCNH2 | |
| SCHEMBL9318018 | 0.74 | CYP19A1 (0.44) | CYP19A1 | |
| SCHEMBL29843057 | 0.74 | CYP19A1 (0.44) | CYP19A1 | |
| SCHEMBL4371413 | 0.73 | AR (0.41) | MBOAT4CYP19A1ARKCNH2 | |
| SCHEMBL9114762 | 0.73 | AR (0.43) | MBOAT4CYP19A1ARKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |