Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176859 | 1.00 | AKR1C3 (0.50) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL6169877 | 0.84 | AKR1C1 (0.55) | AKR1C3KDM4ELMNAMAPTNPSR1 | |
| SCHEMBL6169883 | 0.84 | AKR1C1 (0.55) | AKR1C3KDM4ELMNAMAPTNPSR1 | |
| SCHEMBL6168232 | 0.82 | AKR1C3 (0.59) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL6168237 | 0.82 | AKR1C3 (0.59) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL29293786 | 0.78 | ALDH1A1 (0.54) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL6516511 | 0.74 | AKR1C3 (0.44) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL6516514 | 0.74 | AKR1C3 (0.44) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL20415245 | 0.73 | AKR1C3 (0.50) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL20415242 | 0.73 | AKR1C3 (0.50) | AKR1C3KDM4ELMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |