SCHEMBL6177016

SCHEMBL6177016

C=C(Br)C(=O)Nc1ccc2c(c1)cc(C(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCC(N)=O)n(C)c4)n(C)c3)n(C)c1)n2C

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HRAS P01112 13/20 0.58
ESR1 P03372 13/20 0.58
ESR2 Q92731 13/20 0.58
TOP1 P11387 2/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 1/20 0.46
POLB P06746 1/20 0.46
HIF1A Q16665 1/20 0.46
THRB P10828 1/20 0.42
RXFP1 Q9HBX9 1/20 0.41
ITGB3 P05106 1/20 0.41
ITGA2B P08514 1/20 0.41
HDAC3 O15379 1/20 0.39
HDAC1 Q13547 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6977455 0.93 HRAS (0.67) HRASESR1ESR2TOP1MAPT
SCHEMBL6976357 0.93 HRAS (0.67) HRASESR1ESR2TOP1MAPT
Hydrochloric Acid SCHEMBL6179071 0.92 HRAS (0.67) HRASESR1ESR2TOP1MAPT
Hydrochloric Acid SCHEMBL6972477 0.92 HRAS (0.67) HRASESR1ESR2TOP1MAPT
SCHEMBL6178824 0.92 HRAS (0.55) HRASESR1ESR2TOP1MAPT
SCHEMBL7119707 0.88 HRAS (0.57) HRASESR1ESR2TOP1MAPT
SCHEMBL7127221 0.88 HRAS (0.57) HRASESR1ESR2TOP1MAPT
SCHEMBL6177036 0.87 HRAS (0.49) HRASESR1ESR2TOP1MAPT
SCHEMBL6975216 0.84 HRAS (0.69) HRASESR1ESR2TOP1MAPT
SCHEMBL6178013 0.84 HRAS (0.59) HRASESR1ESR2TOP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064281-B1 BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-05-25 EP claimed
US-6458768-B1 ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS PHARMACIA & UPJOHN, S.P.A. (IT) 2002-10-01 US claimed
EP-1064281-B1 BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-05-25 EP disclosed
US-6458768-B1 ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS PHARMACIA & UPJOHN, S.P.A. (IT) 2002-10-01 US disclosed