SCHEMBL6178013

SCHEMBL6178013

C=C(Br)C(=O)Nc1ccc2oc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)Nc5cc(C(=O)NCCC(N)=O)n(C)c5)n(C)c4)n(C)c3)cc2c1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRAS P01112 13/20 0.59
ESR1 P03372 13/20 0.59
ESR2 Q92731 13/20 0.59
TOP1 P11387 2/20 0.45
MAPT P10636 3/20 0.44
KDM4E B2RXH2 2/20 0.44
POLB P06746 1/20 0.44
HIF1A Q16665 1/20 0.44
ALDH1A1 P00352 2/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 4/20 0.37
NPC1 O15118 3/20 0.37
HPGD P15428 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
ATM Q13315 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6975457 0.93 HRAS (0.68) HRASESR1ESR2TOP1MAPT
Hydrochloric Acid SCHEMBL6976238 0.93 HRAS (0.68) HRASESR1ESR2TOP1MAPT
SCHEMBL6177271 0.91 HRAS (0.58) HRASESR1ESR2TOP1MAPT
SCHEMBL7127221 0.86 HRAS (0.57) HRASESR1ESR2TOP1MAPT
SCHEMBL7119707 0.86 HRAS (0.57) HRASESR1ESR2TOP1MAPT
SCHEMBL6177016 0.84 HRAS (0.58) HRASESR1ESR2TOP1MAPT
SCHEMBL6776573 0.80 HDAC1 (0.49) HRASESR1ESR2TOP1MAPT
SCHEMBL3672404 0.79 HRAS (0.70) HRASESR1ESR2TOP1MAPT
SCHEMBL3680040 0.79 HRAS (0.70) HRASESR1ESR2TOP1MAPT
SCHEMBL6782496 0.79 HDAC1 (0.51) HRASESR1ESR2TOP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064281-B1 BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-05-25 EP claimed
US-6458768-B1 ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS PHARMACIA & UPJOHN, S.P.A. (IT) 2002-10-01 US claimed
EP-1064281-B1 BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-05-25 EP disclosed
US-6458768-B1 ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS PHARMACIA & UPJOHN, S.P.A. (IT) 2002-10-01 US disclosed