Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177061 | 1.00 | NPSR1 (0.63) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6177055 | 1.00 | NPSR1 (0.63) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6178042 | 0.86 | TRPA1 (0.56) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL19500995 | 0.86 | NPSR1 (0.62) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13941966 | 0.85 | NPSR1 (0.62) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13941964 | 0.85 | NPSR1 (0.62) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29278809 | 0.81 | NPSR1 (0.68) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28041776 | 0.78 | NPSR1 (0.56) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29997768 | 0.77 | NPSR1 (0.52) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6177618 | 0.76 | PSEN1 (0.69) | NPSR1MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | claimed |
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |