Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | THPO | P40225 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976296 | 0.82 | HDAC1 (0.55) | RAD52EGFRERBB2HDAC1 | |
| SCHEMBL6976301 | 0.79 | BCL2L1 (0.45) | BCL2L1GPR35TBXAS1LMNAEGFR | |
| SCHEMBL28327391 | 0.77 | BCL2L1 (0.54) | BCL2L1GPR35TBXAS1ALDH1A1LMNA | |
| SCHEMBL6977328 | 0.75 | HDAC6 (0.44) | RAD52ALDH1A1SMN1; SMN2HIF1ALMNA | |
| SCHEMBL29742282 | 0.72 | BCL2L1 (0.59) | BCL2L1GPR35TBXAS1MEN1KMT2A | |
| SCHEMBL740202 | 0.72 | BCL2L1 (0.59) | BCL2L1GPR35TBXAS1CLK1DYRK1A | |
| SCHEMBL2897390 | 0.72 | BCL2L1 (0.59) | BCL2L1GPR35TBXAS1MEN1KMT2A | |
| SCHEMBL29742302 | 0.72 | BCL2L1 (0.59) | BCL2L1GPR35TBXAS1CLK1DYRK1A | |
| SCHEMBL4082326 | 0.70 | BCL2L1 (0.61) | BCL2L1GPR35TBXAS1SMN1; SMN2LMNA | |
| SCHEMBL2194399 | 0.70 | DYRK1A (0.71) | BCL2L1GPR35TBXAS1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064281-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-25 | — | — | EP | disclosed |
| EP-0937070-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA ITALIA SPA (IT) | 2003-12-03 | — | — | EP | disclosed |
| US-6458768-B1 | ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2002-10-01 | — | — | US | disclosed |
| US-6153642-A | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-28 | — | — | US | disclosed |