Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CACNA2D2 | Q9NY47 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170104 | 0.86 | NPC1 (0.54) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6096068 | 0.76 | CYP1A2 (0.52) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6096794 | 0.74 | CYP1A2 (0.56) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6094567 | 0.74 | KDM4E (0.50) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6095421 | 0.74 | CYP1A2 (0.50) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL28834473 | 0.70 | MEN1 (0.43) | SMN1; SMN2KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL21777166 | 0.70 | NQO1 (0.50) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL13362180 | 0.69 | NPC1 (0.51) | HPGDSMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL1875887 | 0.67 | NPC1 (0.57) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL31500060 | 0.67 | SMN1; SMN2 (0.69) | HPGDSMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495005-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | Pfizer Japan Inc. (JP) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087061-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |