Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177322 | 0.87 | CYP1A2 (0.42) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL6177927 | 0.86 | HPGD (0.42) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL6173067 | 0.84 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL1872553 | 0.76 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL16872802 | 0.75 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL21208579 | 0.74 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL14439485 | 0.73 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL28834473 | 0.73 | MEN1 (0.43) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL6098356 | 0.73 | CYP1A2 (0.54) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL29050457 | 0.72 | CYP1A2 (0.52) | NPC1RAB9ASMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495005-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | Pfizer Japan Inc. (JP) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087061-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |