Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 13/20 | 0.66 |
| ▸ | TGM2 | P21980 | 3/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29758460 | 0.79 | CES1 (1.00) | CES1TGM2DNMT1HTR6 | |
| SCHEMBL124586 | 0.79 | CES1 (1.00) | CES1TGM2DNMT1HTR6 | |
| SCHEMBL1398084 | 0.76 | CES1 (0.66) | CES1TGM2DNMT1MAOAMAOB | |
| SCHEMBL8569668 | 0.76 | CES1 (0.66) | CES1TGM2DNMT1MAOAMAOB | |
| SCHEMBL6176815 | 0.74 | CES1 (0.69) | CES1TGM2DNMT1MAOAMAOB | |
| SCHEMBL6179642 | 0.74 | CES1 (0.41) | CES1TGM2BCHE | |
| SCHEMBL8873852 | 0.73 | CES1 (0.88) | CES1TGM2DNMT1HTR6 | |
| SCHEMBL6179714 | 0.71 | CES1 (0.44) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL8923330 | 0.71 | CES1 (0.58) | CES1TGM2DNMT1 | |
| SCHEMBL8555179 | 0.71 | CES1 (0.41) | CES1TGM2HTR6CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| EP-1105376-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010975-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-03-02 | — | — | WO | disclosed |