Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 9/20 | 0.44 |
| ▸ | TGM2 | P21980 | 6/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | ARAF | P10398 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | MYOC | Q99972 | 1/20 | 0.33 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15242441 | 0.80 | CES1 (0.47) | CES1TGM2BCHEALDH1A1ALDH2 | |
| SCHEMBL6176815 | 0.77 | CES1 (0.69) | CES1TGM2BCHEMAOAMAOB | |
| SCHEMBL16419647 | 0.77 | CES1 (0.44) | CES1TGM2BCHEALDH1A1ALDH2 | |
| SCHEMBL31353351 | 0.77 | ALDH1A1 (0.53) | CES1TGM2BCHEALDH1A1ALDH2 | |
| SCHEMBL22939438 | 0.74 | CES1 (0.42) | CES1TGM2BCHERAF1MAP1LC3B | |
| SCHEMBL3726368 | 0.73 | CES1 (0.41) | CES1TGM2 | |
| SCHEMBL31381684 | 0.73 | CES1 (0.41) | CES1TGM2 | |
| SCHEMBL8574395 | 0.73 | CES1 (0.41) | CES1TGM2BCHEALDH1A1ALDH2 | |
| SCHEMBL6178034 | 0.71 | CES1 (0.66) | CES1TGM2BCHEMAOAMAOB | |
| SCHEMBL22938881 | 0.68 | AURKA (0.43) | CES1BCHERAF1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| CN-1161333-C | Oxindole derivatives as growth hormone releasers | ס����ҩ��ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| CN-1313853-A | Oxindole derivatives as growth hormone releasers | SUMITOMO PHARMA (JP) | 2001-09-19 | — | — | CN | disclosed |
| EP-1105376-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010975-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-03-02 | — | — | WO | disclosed |