SCHEMBL6178399

SCHEMBL6178399

CC(C)(C)OC(=O)NC1CN(C(=O)C2CCCC2)c2ccccc2NC1=O

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.43
IDH1 O75874 5/20 0.43
BRD4 O60885 1/20 0.42
PIM1 P11309 1/20 0.41
PIM3 Q86V86 1/20 0.41
PIM2 Q9P1W9 1/20 0.41
GAA P10253 2/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
IDO1 P14902 1/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MAPK10 P53779 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176160 0.99 IDH1 (0.45) EPHX2IDH1BRD4PIM1PIM3
SCHEMBL6175840 0.96 EPHX2 (0.45) EPHX2IDH1PIM1PIM3PIM2
SCHEMBL6176634 0.87 EPHX2 (0.46) EPHX2PIM1PIM3PIM2GAA
SCHEMBL6177881 0.87 GAA (0.38) EPHX2BRD4PIM1PIM3PIM2
SCHEMBL6179377 0.87 EPHX2 (0.43) EPHX2PIM1PIM3PIM2GAA
SCHEMBL6175654 0.86 EPHX2 (0.46) EPHX2BRD4PIM1PIM3PIM2
SCHEMBL6176374 0.86 EPHX2 (0.46) EPHX2PIM1PIM3PIM2GAA
SCHEMBL7960759 0.86 GAA (0.37) EPHX2BRD4PIM1PIM3PIM2
SCHEMBL15799246 0.85 EPHX2 (0.45) EPHX2PIM1PIM3PIM2GAA
SCHEMBL6176897 0.84 EPHX2 (0.44) EPHX2PIM1PIM3PIM2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945445-B9 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2005-12-28 EP disclosed
EP-0945445-B1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-09-03 EP disclosed
US-6239131-B1 WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-05-29 US disclosed
EP-0945445-A1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed