Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | GLS | O94925 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4339530 | 0.92 | MAPK14 (0.53) | MAPK14USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6175778 | 0.86 | MAPK14 (0.52) | MAPK14MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13785079 | 0.85 | MAPK14 (0.54) | MAPK14MAPTKDM4ECSNK1DCSNK1E | |
| SCHEMBL4337031 | 0.85 | MAPK14 (0.52) | MAPK14ROCK1MAPTMEN1KMT2A | |
| SCHEMBL6178426 | 0.85 | MAPK14 (0.56) | MAPK14MAPTKDM4ECSNK1DCSNK1E | |
| SCHEMBL4329813 | 0.85 | MAPK14 (0.56) | MAPK14ROCK1MEN1KMT2AKDM4E | |
| SCHEMBL4335571 | 0.85 | NR3C2 (0.46) | MAPK14TP53MAPTMEN1KMT2A | |
| SCHEMBL6179743 | 0.84 | MAPK14 (0.55) | MAPK14ROCK1MAPTKDM4ECSNK1D | |
| SCHEMBL4338017 | 0.84 | MAPK14 (0.55) | MAPK14KDM4ECSNK1DCSNK1E | |
| SCHEMBL4329196 | 0.84 | MAPK14 (0.55) | MAPK14KDM4ECSNK1DCSNK1ESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |