Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.33 |
| ▸ | VKORC1 | Q9BQB6 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176220 | 0.86 | VKORC1 (0.37) | CYP2C9VKORC1LMNATP53MAPT | |
| SCHEMBL27333913 | 0.85 | VKORC1 (0.36) | HPGDCYP2C9VKORC1LMNATP53 | |
| SCHEMBL6174712 | 0.84 | HPGD (0.33) | HPGDCYP2C9VKORC1LMNATP53 | |
| SCHEMBL9201359 | 0.83 | CYP2C9 (0.33) | HPGDCYP2C9VKORC1LMNAGAA | |
| SCHEMBL6174524 | 0.82 | CYP2C9 (0.36) | CYP2C9VKORC1 | |
| SCHEMBL9199733 | 0.81 | ELANE (0.33) | HPGDCYP2C9VKORC1LMNATP53 | |
| SCHEMBL6176564 | 0.81 | CYP2C9 (0.39) | HPGDCYP2C9VKORC1KDM4EALDH1A1 | |
| SCHEMBL7541486 | 0.81 | VKORC1 (0.35) | CYP2C9VKORC1KDM4EALDH1A1ALB | |
| SCHEMBL6177695 | 0.80 | CYP2C9 (0.38) | CYP2C9VKORC1MAPTALDH1A1HSD17B10 | |
| SCHEMBL9193978 | 0.80 | MAPK1 (0.34) | HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |