Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.31 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174712 | 0.93 | HPGD (0.33) | MAPTHPGDCYP2C9VKORC1LMNA | |
| SCHEMBL9197301 | 0.89 | ELANE (0.34) | ELANEMAPTHTR2BCYP2C9VKORC1 | |
| SCHEMBL9197893 | 0.89 | HPGD (0.40) | HPGDCYP2C9LMNACYP3A4CYP2D6 | |
| SCHEMBL9196698 | 0.87 | MEN1 (0.40) | HPGDCYP2C9LMNACYP3A4CYP2D6 | |
| SCHEMBL6173304 | 0.87 | HTR2B (0.43) | ELANEHTR2B | |
| SCHEMBL9198707 | 0.87 | CEL (0.41) | VKORC1LMNATP53 | |
| SCHEMBL9198902 | 0.86 | PPARG (0.32) | ELANEMAPT | |
| SCHEMBL6175129 | 0.86 | ELANE (0.33) | ELANEMAPTHTR2BCYP2C9VKORC1 | |
| SCHEMBL9201135 | 0.86 | ELANE (0.47) | ELANEMAPTHPGD | |
| SCHEMBL9199339 | 0.86 | ELANE (0.47) | ELANEMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | claimed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | disclosed |